This story is about
the ancient ancestors of Darnell L Williams. In a place far, far away. In a
time long ago. It is in a time before anyone thought about the Williams,
Browns, Blues, Thorns, or the rest. It was before the time anyone thought about
the United States or many other nations. It even goes back before a time when
race was a factor in society.
Before we start
talking about my DNA, we should talk about the myths that a DNA Test will show
people. It shows who people are or were they come from. However, having said
that, people travel all over the Earth. The people who built the Pyramids in
Egypt may have moved to West Africa. The people living among the Pyramids today,
may have come to Egypt in the last 3,000 years after the Pyramids became an ancient
place to live.
The people
who now live in Western Africa, may have moved from Egypt when the Sahara Desert
was the Sahara Rain Forest, 8,000 years ago.
The DNA that you have
may show that you are Egyptian (with DNA from a Data Base taken from people in
the past 50 years) but actually, you are Greek of people 3,000 years ago. So I am telling you that your DNA may tell
you little about the nationality that your ancient ancestors are really from.
Lauren Gamber wrote a
story called, "DNA Fact or Science Fiction." This document may shed
some light on what I am trying to tell you.
*****
DNA Fact or Science
Fiction?
11/6/2009
By Lauren Gamber
Discover
the truth behind six common genetic genealogy misconceptions—and figure out how
DNA testing really fits into your
family tree search.
family tree search.
Jenny Oligos suspected that her great-grandparents had emigrated
from Piraeus, Greece, just like her friend Helen’s (Helen and Jenny have the
same maiden name), but she couldn’t locate the documentation to prove her
hunch. After years of scouring immigration records, she finally found
her holy grail.
A second cousin who collected family heirlooms gave Jenny their
great-grandmother’s hairbrush, which still contained a few wispy strands. Jenny
had heard that scientists can use the DNA in hair to trace a person’s genetic
origins. She carefully wrapped the brush and sent it to a DNA testing company
for analysis. Because Helen had already confirmed through records that her
ancestors had emigrated from Piraeus, she sent a sample of her own hair to the
company for comparison.
Six weeks later, Jenny received a full report that provided the
answers she’d sought for years. Not only did she find out that her ancestors
had in fact hailed from Piraeus, but she also learned that she and Helen are
fourth cousins.
The company even identified who Jenny and Helen’s common
ancestors are. Cousins currently living in Greece had obtained samples of their
ancestors’ DNA by exhuming their bodies. They’d submitted the DNA samples to
the same testing company, which maintains a database genealogists can use to
find genetic matches. Now that Jenny has identified her family’s origins, she
can focus her research efforts.
Does this tale of genealogical discovery sound far-fetched?
That’s because it is. Jenny Oligos is a figment of imagination. The story
illustrates common misconceptions about DNA testing, the latest trend in family
history research and the source of much confusion—and even fear. Let’s tackle
those misconceptions one by one so you can learn the truth about your
genetic genealogy testing options.
Myth 1: Geneticists use hair and blood samples to trace a
person’s ancestry.
Although scientists do utilize hair and blood samples for
paternity tests and forensic analysis, there’s no need to draw blood or pluck
hairs for a genetic genealogy test. When you order a DNA test for yourself or
someone else, you’ll receive a cheek-swab kit or a mouthwash kit in the
mail—complete with instructions, a consent form and a return envelope. For the
cheek-swab kit, you’ll use a sterile swab or toothbrush-like device to
painlessly scrape the inside of your cheek for a few seconds. (The company may
provide multiple swabs in order to obtain backup cheek-cell samples, just in
case the first one doesn’t yield clear results.) For the mouthwash kit, you’ll
swish the supplied rinse for a specified amount of time and spit it back into
the container. Then you’ll just sign the consent form and mail it and your DNA
sample back to the company. You should receive results in the mail or on a
password-protected Web site within a few weeks.
Reality check: So could “Jenny”
have sent her great-grandmother’s hair to a DNA lab for testing? There are
forensic labs that test hair, but this type of analysis comes with a much
higher price tag.
Myth 2: A DNA test can pinpoint precisely where your ancestors
lived or which tribe they belonged to.
If your ancestors and their offspring had stayed in one
geographic region and never allowed outsiders to enter, it would be relatively
easy to distinguish their DNA (and yours) from the DNA of people living in
other regions. Over time, all of the inhabitants of your region would come to
share specific genetic mutations (usually harmless changes in DNA), which would
identify them as a distinct population, the same way a surname identifies
members of a family.
But our ancestors didn’t stay in one place. For thousands of years, humans have moved about, leaving their genetic imprints wherever they procreate and making it increasingly difficult for geneticists to distinguish one region’s population from another’s.
Scientists can make inferences about your ancestry based on
trends among populations, but they can’t say for sure that your ancestors lived
in a specific country, much less a specific town. Testing companies analyze a
person’s genetic makeup by comparing his or her DNA to a reference database of
DNA samples from modern individuals living in various regions—such as residents
of present-day African countries (turn the page for more on African-American
DNA testing). But it’s important to keep in mind that today’s inhabitants of a
given region are genetically different from the people who lived there before
migration occurred. Just because your DNA matches the DNA of someone who
currently lives there, that doesn’t necessarily mean your ancestors came from
that place. Likewise, your DNA might match that of a modern-day African tribe,
but your ancestors may not have identified with that particular group.
Biogeographical tests such as DNA Testing Systems’ DNA Fingerprint tests will
estimate where in the world your ancestors originated. Yet scientists haven’t
agreed upon definitions for even broad genetic ethnicities, so if you test with
more than one company, you may get different results.
By combining genetic genealogy and traditional genealogical
research methods, however, you can make headway in pinpointing your family’s
origins. As more people get tested and contribute both their DNA test results
and their family trees to online databases (see myth 5 for more on these),
scientists will be able to identify additional patterns and draw better
conclusions.
Reality check: While browsing a
database, Jenny might have noticed that her close relatives’ DNA matches the
DNA of people with confirmed roots in a certain part of Greece. She could then
focus her research efforts on that locale. But at this point, it’s unrealistic
to expect a DNA testing company to provide that level of assurance in your test
results.
Myth 3: To find out if you and another researcher descend from
the same third-great-grandfather, you need to dig up his body for a DNA sample
to test.
We strongly recommend letting Great-grandpa rest in peace. There
are easier ways to prove a genetic link that don’t involve literally turning
relatives over in their graves.
To find out if you and someone else descend from the same male
ancestor, you should turn to Y-DNA testing. The Y chromosome (also called
Y-DNA) is passed virtually unchanged from father to son, just like (in most cases)
a surname. So Great-grandpa should have the same Y-DNA as his son, his son’s
son and so on. You can use Y-DNA to trace your paternal lineage, which is
represented by the top line of a pedigree chart.
If you and your fellow researcher are both male and have the
same surname as the man you think is your third-great-grandfather, then you
both should have your Y-DNA tested. (Even if one of you has a different
surname, you still could be related; a surname might’ve changed after an
adoption or during an immigrant ancestor’s assimilation process.) If you’re
indeed related, your Y-DNA test results should be identical or nearly
identical, because mutations do occur occasionally.
But even with a perfect match, there’s no telling whether you’re
related through your third-great-grandfather or a different ancestor, unless
you can find the records to prove your hypothesis. That’s because mutations
don’t occur at regular intervals, so it’s hard to predict exactly when the most
recent common ancestor (MRCA) might’ve lived. Most DNA testing companies
provide an estimate, though.
Because women don’t have Y chromosomes, a female researcher
would need to turn to someone with the same Y-DNA as her biological father. She
could ask her father, brother, uncle (her father’s brother), a male cousin (her
father’s brother’s son) or a nephew (her brother’s son) to take a Y-DNA test.
Geneticists use another type of DNA, called mitochondrial DNA (mtDNA), to trace maternal lineage, what’s shown on the bottom line of a pedigree chart. Mothers pass their mtDNA to their daughters and their sons, but only daughters pass mtDNA on to the next generation.
Genealogists can use mtDNA in much the same
way as Y-DNA, although it’s not as useful because it doesn’t correspond to
surnames. Plus, mtDNA mutates more slowly than Y-DNA does, making it even
harder to predict when an MRCA might’ve lived.
Typically, genealogists use mtDNA to explore their ancient
ancestry or to weed out people who aren’t related through their maternal lines.
If your mtDNA results don’t match exactly with someone else’s, you’re probably
not closely related. Rarely do two people with one or more differences in their
mtDNA have a common ancestor who lived recently enough that she might appear in
written records.
Testing your own or a close relative’s Y-DNA or mtDNA can reveal
information about your paternal line (your father’s father’s father) and your
maternal line (your mother’s mother’s mother) but not about anyone in between.
But you can enlist the assistance of your male and female cousins to learn
about the ancestors named in the middle of your pedigree chart.
Reality check: To find out if they’re related, Jenny and Helen could’ve had their mtDNA tested (using cheek-cell or saliva samples, not hair). If their results had revealed an exact match, though, Jenny and Helen couldn’t have known when the MRCA on their maternal line lived without turning to traditional roots resources—that ancestor could’ve walked the earth hundreds of years ago.
The two women also could’ve asked male relatives to get their
Y-DNA tested. The DNA company would have been able to use those test results to
estimate with more precision when the MRCA on their paternal line might’ve
lived—for instance, a 12-marker match might mean there’s an 80 percent chance
they share an ancestor within the past 15 generations—but again, this would be
just an estimate. Geneticists wouldn’t be able to tell them that they’re fourth
cousins. Which leads us to the next myth.
Myth 4: The results of ancestral DNA tests are 99.9 percent
accurate, just like the DNA tests on CSI.
Genetic genealogy isn’t an exact science—it involves quite a bit
of interpretation. Although your DNA doesn’t lie, scientists use it to
calculate the probability that you and another researcher are related or that
you have African roots, based on genetic patterns they’ve observed in
populations. This means that genetic genealogy can suggest, but not prove, a
relationship.
Biogeographical test results in particular must be taken with a
grain of salt, because scientists haven’t agreed upon definitions of genetic
ethnicity. What makes interpreting results from biogeographical tests even
trickier is that these tests rely on autosomal DNA, a mixed bag of genetic
information inherited from both mothers and fathers. A test may suggest that
you have some American Indian ancestry, but you won’t know whether it comes
from your mother’s side or your father’s side unless both of your parents get
tested as well. Nor will you know how long ago your American Indian ancestor
(or ancestors) lived.
Interpreting Y-DNA test results also presents some challenges.
The number of Y chromosome markers you get tested influences the reliability of
these tests. Men can choose to test between 12 and 67 markers. The more markers
tested, the greater the chance of finding genetic mutations (or differences)
and, therefore, the smaller the chance of having an exact genetic match. In
other words, a 67-marker test is more precise than a 12-marker test, and less
likely to imply a “false positive” relationship. It’s also more expensive.
If two men have the same surname and the same Y-DNA test
results, there’s a very good chance they’re related within a genealogically
significant time period. One or two different marker values, depending on the
number of markers tested, also could indicate a genetic link.
Remember that a
genetic mutation can occur at any time, so even a father’s and son’s results
might not match exactly, although this rarely occurs.
The Sorenson Molecular Genealogy Foundation (SMGF), which offers Y-DNA, mitochondrial DNA and autosomal
DNA databases, generally recommends that genealogists order
36-marker Y-DNA tests. According to the SMGF Web site, two men with the same
surname who match 34 out of 36, 35 out of 36, or 36 out of 36 markers probably
have a common ancestor who lived within the past 500 years. Two men with
different surnames but with at least a 34 out of 36 match also may have a
common ancestor who lived in the recent past. Fewer matches may indicate a
connection before the widespread use of public records.
Geneticists know that some markers mutate faster than others, and they take this into consideration when interpreting test results. But you can see why different mutation rates can make predicting when an MRCA might’ve lived even more difficult.
Reality check: Again, a testing
company wouldn’t have told Jenny and Helen how many generations back their MRCA
lived. The company might have provided a range based on probability.
Myth 5: If you take a DNA test, you can finally find out who
your great-grandmother’s parents were.
Your DNA test results won’t reveal your ancestors’ names, but
you can use them to do a little detective work online. Plug your Y-DNA marker
values—or your relative’s—into a public DNA database, and you may connect with
other genealogists who have the same haplotype. (“Haplotype” refers to a series
of marker values. Your haplotype is essentially a list of numbers, each
corresponding to a DNA marker.)
You may find that people with the same haplotype as you all live
in the same region or even the same country. Although you won’t know for sure
that your ancestors hailed from that place, you may want to do some further
investigating in written records. Of course, you’ll want to pay particular
attention to any genetic matches whose surnames are the same or similar to
yours. By swapping notes with these DNA cousins, you might just figure out who
your great-grandmother’s parents were. But you won’t make this discovery
through DNA testing alone.
Regardless of which company provided your test, you can
contribute your results to any public online database. Once you sign up for a
database, you may receive an e-mail notification each time someone with your
haplotype adds his test results. We also recommend joining a surname or
geographic project to meet people who share your surname or whose ancestors
lived in the same region as yours. You can join a project before or after
having your DNA tested.
You can upload your DNA test results and your family tree to Web
sites such asGeneTree and the SMGF database. Once you meet genetic
matches, you can let them view your family tree online, which saves you the
trouble of mailing files back and forth.
Reality check: A DNA test can’t
tell you your ancestors’ names, let alone the ancestors you share with someone
else. But if you connect with a researcher whose haplotype matches yours, you
may add to your family tree simply by sharing what you already know.
Myth 6: “Big Brother” could get your DNA if you try genetic
genealogy.
Does the idea of your DNA test results’ ending up in an online
database make you nervous? Testing companies take your privacy seriously, and
they won’t post your results on the Internet without your consent. If you do
want to include your information in an online database, you can determine how
much personal information you want to reveal.
Testing companies also make a point of safeguarding customers’
DNA specimens—attaching a bar code, not personal information, to each sample,
for instance. Some companies destroy all samples after analyzing them. Others
give customers the choice of having their specimens destroyed or allowing the
company to securely store their samples for any additional tests. To learn more
about a company’s privacy policy, check its Web site or make a phone call.
Even though Y-DNA is passed from father to son, a Y-DNA test
isn’t a paternity test. The results can disprove paternity, but they can’t be
used to prove paternity in court. Law enforcement officials could potentially
use DNA test results databases to further an investigation—a controversial
topic in the scientific community—but it’s unlikely they’d be able to identify
a specific suspect using genetic genealogy research.
Reality check: Rest assured.
Getting your Y-DNA or mtDNA tested won’t open you up to identity theft,
criminal investigation or paternity suits. But it may introduce you to new
research avenues, so you can write your own (true) success story.
From the December 2009 Family Tree Magazine.
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